| Date | Opponent | Location | Time/Result (CST) |
| Feb. 4 | vs. Northwestern (IA) | Metrodome | W, 7-6 ; L, 4-5 |
| Feb. 15 | vs. St. Cloud State | Metrodome | L, 8-9 (12) ; 1-0^ |
| Feb. 21 | vs. Nebraska-Kearney | Metrodome | W, 4-3 (8) ; L, 3-4 |
| Feb. 24 | vs. St. John's (MN) | Metrodome | L, 0-4 ; L, 8-9 |
| Feb. 25 | vs. Kansas Wesleyan | Metrodome | L, 2-3; W, 2-1 |
| Mar. 5-15 | 2010 Spring Trip | Orlando, FL | 8 Games |
| Mar. 6 | vs. West Virginia Wesleyan | Orlando, FL | W, 5-4 |
| Mar. 7 | vs. Southwest Minnesota State | Orlando, FL | W, 5-2; W, 5-1 |
| Mar. 8 | vs. St. Joseph's (IN) | Orlando, FL | L, 6-13 |
| Mar. 9 | vs. Saginaw Valley State (MI) | Orlando, FL | L, 2-13 |
| Mar. 11 | vs. #25 Nebraska-Omaha | Orlando, FL | W, 5-1 |
| Mar. 12 | vs. #23 Ashland (OH) | Orlando, FL | Cancelled |
| Mar. 13 | vs. Southwest Minnesota State | Orlando, FL | Cancelled |
| Mar. 20 | at Augustana* | Barnes Field | 1:30 (9/7) |
| Mar. 21 | at Augustana* | Barnes Field | 12:00 (9/7) |
| Mar. 24 | Minnesota Duluth | Barnes Field | 2:00 (7/7) |
| Mar. 27 | vs. UW-La Crosse | Metrodome | 5:30 (7/7) |
| Mar. 30 | at Minnesota Duluth | Duluth, MN | 2:00 (7/7) |
| Apr. 1 | Wayne State* | Barnes Field | 2:00 (9/7) |
| Apr. 2 | Wayne State* | Barnes Field | 12:00 (9/7) |
| Apr. 6 | at Northern State* | Aberdeen, SD | 2:00 (9/7) |
| Apr. 10 | at St. Cloud State* | St. Cloud, MN | 1:00 (9/7) |
| Apr. 11 | at St. Cloud State* | St. Cloud, MN | 1:00 (9/7) |
| Apr. 14 | Northern State* | Barnes Field | 2:00 (9/7) |
| Apr. 17 | Minnesota, Crookston* | Barnes Field | 1:00 (9/7) |
| Apr. 18 | Minnesota, Crookston* | Barnes Field | 12:00 (9/7) |
| Apr. 21 | at #30 Minnesota State* | Mankato, MN | 1:30 (9/7) |
| Apr. 24 | Bemidji State* | Barnes Field | 1:00 (9/7) |
| Apr. 25 | Bemidji State* | Barnes Field | 12:00 (9/7) |
| Apr. 28 | #30 Minnesota State* | Barnes Field | 1:30 (9/7) |
| May 1 | at #28 Winona State* | Winona, MN | 1:00 (9/7) |
| May 2 | at #28 Winona State* | Winona, MN | 12:00 (9/7) |
| May 5-8 | NSIC Tournament | St. Cloud, MN | TBA, Double Elim |
| May 12-17 | NCAA Central Regional | TBA | TBA, Double Elim |
| May 22-29 | NCAA World Series | Appleton, WI | TBA, Double Elim |
| * - NSIC games ; all games p.m. start time unless otherwise noted rankings based on Collegiate Baseball News Division II National Poll ^ - game suspended with CU leading 1-0 in bottom of 4th inning, will be resumed at a later date | |||
